Beilstein J. Org. Chem.2020,16, 2523–2533, doi:10.3762/bjoc.16.204
the validation of 3D glycoprotein structures.
Keywords: electroncryomicroscopy; glycoinformatics; glycomics; Privateer; X-ray crystallography; Introduction
Glycosylation-related processes are prevalent in life. The attachment of carbohydrates to macromolecules extends the capabilities of cells to
glycoproteins
Several experimental techniques can be used to obtain 3D structures of glycoproteins: X-ray crystallography (MX, which stands for macromolecular crystallography), nuclear magnetic resonance spectroscopy (NMR) and electroncryomicroscopy (cryo-EM). As of publication date, the overwhelming majority
PDF
Graphical Abstract
Figure 1:
Comparison of the glycan features in electron density maps over a range of resolutions from selecte...